W. Wang K. Virtanen Dowell Barak Kelly I. Zhang Kelly M. P. 1997;18 Suppl 4:S308–9. The age-associated fibrosis notwithstanding, cardiac function is relatively normal in young PPARα null mice. Chakrabarti Jove Tarr However, the response to several physiologic stressors is perturbed in mice lacking PPARα. Yue B.A. *FREE* shipping on qualifying offers. Finck et al. K. J.G. J.J. Reaven Mounting evidence suggests that the metabolic products of angiotensin I and II - initially thought to be biologically inactive - have key roles in cardiovascular physiology and pathophysiology. Kosm Biol Aviakosm Med. over 30 years ago . Aviat Space Environ Med. Gavrilova J Appl Physiol. W. Campbell Weinheimer Thus, the end effects of PPAR/PGC-1α activity on pathologic remodeling are less than clear. Studies characterizing both strains of PGC-1α-deficient mice demonstrate perturbations in mitochondrial OXPHOS pathway function and depressed expression of genes encoding enzymes involved in these pathways. V. Microgravity Q. Ruiz-Lozano Physiology: A Regulatory Systems Approach [Strand, Fleur L.] on Amazon.com. National Aeronautics and Space Administration. Lane HW, Smith SM. R.M. J Urol. Barger Smith SM, Heer MA, Shackelford L, Sibonga JD, Ploutz-Snyder L, Zwart SR. Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: evidence from biochemistry and densitometry. 1986;20(4):84–6. The endocrine and metabolic responses to space flight. C. Papageorgiou 1997;20(6):547–51. 1998;148(5):445–51. P.J. Review of basic medical results of the Salyut-7–Soyuz-T 8-month manned flight. Acta Astronaut. Metabolic consequences of fluid shifts induced by microgravity. A. Augustus Am J Clin Nutr. In: David D, editors. H.C. D.P. Physiology Unit 1 Homeostasis . JAMA. A. 2012;51(4):756–64. 1998;11(2):51–60. PPARγ which is adipose-enriched, controls the expression of genes involved in fatty acid storage and adipogenesis. The pathologic mechanisms whereby these metabolic abnormalities are still incompletely understood. M. Reversal of weightlessness-induced musculoskeletal losses with androgens: quantification by MRI. de las Fuentes M. Aasum Proteins and enzymes known to be regulated by PPARα are indicated by a star. Ohshima H. Bone loss and bone metabolism in astronauts during long-duration space flight. P.J. Indeed, enhanced glucose oxidation during ischemia–reperfusion, especially in insulin resistant or diabetic heart, has been linked to improved recovery . In support of this, partial inhibitors of mitochondrial FAO show promise as therapeutic treatment for cardiac disease [88–90]. Interestingly, the severity of the cardiac phenotype varies greatly between the two lines of null mice. Am J Physiol Endocrinol Metab. Ong Cardiomyopathy and/or conduction defects are also observed in mouse models with targeted deletion of the fatty acid oxidation enzymes [17–19]. Until recently, the PPARβ/δ (referred to as PPARβ from here on) isoform was little-studied. 1967;200:579–83. Finck W. et al. The renin-angiotensin system is an important component of the cardiovascular system. This work was supported by a KO1 award (KO1 DK062903) from the NIDDK and other NIH grants (RO1 DK45416, RO1 HL58493, PO1 HL57278, P30 DK56341, and P30 DK52574). D.S. et al. Handschin F. Calandra A. Sakai Physiologist. T.C. Jones JA, Sargsyan A, Pietrzyk RA, Sams CF, Stepaniak P, Whitson PA. Urolithiasis and genitourinary system issues for spaceflight. Ibdah Unfortunately, constitutive, whole-body disruption of PPARγ results in embryonic lethality due to placental and cardiac defects , preventing the evaluation of the cardiac phenotype of these mice. Hasegawa et al. Changes in hematocrit in humans under conditions of long-term hypokinesia and space flight. In addition, whereas the myocardium utilizes primarily fatty acids in the fasted state, cardiac glucose utilization significantly contributes to ATP synthesis post-prandially . Lee Millington et al. C. et al. N. Stimulation of fluid-electrolyte metabolism as a means of preventing orthostatic instability in the crew of the second expedition aboard the Salyut-4 station. McLaughlin Cho J. A. Torra B.N. Weiss 1992;26(5-6):20–4. Grigoriev AI, Morukov BV, Vorobiev DV. 1979;11(3):10–5. et al. Tsutsui H.J. Urology. Björklund A, Lindvall O. Barak Leach CS. Tesch PA, Berg HE, Bring D, Evans HJ, LeBlanc AD. By the time of the Skylab missions, the laboratory technologies developed by NASA were mature enough to allow some investigations to be performed during flight. Kvetnansky R, Davydova NA, Noskov VB, Vigas M, Popova IA, Usakov AC, et al. J Appl Physiol. Am J Med Sci. New York, NY: Wiley; 1979, p. 337–41. D.J. Altarejos J Appl Physiol. These findings indicate that PPARα-driven reliance on fatty acid utilization and coordinate inhibition of glucose metabolism can lead to pathologic remodeling and severe cardiomyopathy. Noskov VB, editor. Kirsch K, Haenel F, Röcker L. Venous pressure in microgravity. A.W. Rader J Urol. In: Zanjani ED, Tavassoli M, Ascensao JL, editors. Maaß H, Raabe W, Wegmann HM. Y.X. Hello Select your address Books. McMonigal KA, Braverman LE, Dunn JT, Stanbury JB, Wear ML, Hamm PB, et al. Leone D.D. T.A. W. Feige Am J Physiol. Fruchart Nutrition. Bastin Anemia and erythropoietin in space flights. J.C. Radda Clarke Legen’kov VI, Kiselev RK, Gudim VI, Moskaleva GP. Curr Pharm Biotechnol. Two strains of whole-animal constitutive PPARβ knockout mice have been developed [54,55], but the cardiac physiology and metabolic phenotype of these PPARβ null mice has not yet been reported. 1993;264:E824–8. Aviat Space Environ Med. Kosm Biol Aviakosm Med. W. Aizawa The diagram depicts the major routes for ATP production from catabolism of fatty acids and glucose in the cardiac myocyte. M.J. Salazar G. Leach CS, Altchuler SI, Cintron-Trevino NM. C.J. M.M. © 2020 Springer Nature Switzerland AG. M. Schneider VS, LeBlanc A, Huntoon CL. B.N. These examples of inherited metabolic cardiomyopathic disorders highlight the sensitivity of the heart to defects in mitochondrial metabolism. Bungo MW, Charles JB, Johnson Jr PC. M.J. Kelly LeBlanc A, Schneider V, Shackelford L, West S, Oganov V, Bakulin A, et al. J Nutr. Fluid control mechanisms in weightlessness. McCall GE, Goulet C, Roy RR, Grindeland RE, Boorman GI, Bigbee AJ, et al. L. System status; Login My Account Feedback Reporting from: Message. 2010;81(2):91–102. Han Zwart SR, Hargens AR, Smith SM. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Chen Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission duration. Effects of vitamin D and steroid hormones on the active transport of calcium by the intestine. Leach C, Rambaut P, Di Ferrante N. Amino aciduria in weightlessness. et al. Kovacs M. Brian N. Finck, The PPAR regulatory system in cardiac physiology and disease, Cardiovascular Research, Volume 73, Issue 2, January 2007, Pages 269–277, https://doi.org/10.1016/j.cardiores.2006.08.023. Immune responses and latent herpesvirus reactivation in spaceflight. Water and electrolyte studies during long-term missions onboard the space stations Salyut and Mir. Michalik Clarke G.K. Curr Opin Clin Nutr Metab Care. 2014;83(5):1060–4. S.A. Med Sci Sports Exerc. 1983;54(12 Suppl):31–40. Renal stone disease 2, 2nd International Urolithiasis Research Symposium: American Institute of Physics; 2008. pp. Society of Automotive Engineers: Warrendale, PA; 1987. In: Johnston RS, Dietlein LF, editors. Wahli Gardner 1991;34(1 Suppl):S44–8. et al. J Gravit Physiol. In: Shils ME, Olson JA, Shike M, Ross AC, editors. Weinheimer Alfrey CP, Udden MM, Huntoon CL, Driscoll T. Destruction of newly released red blood cells in space flight. Gen et al. Merlos The studies described herein describe the link between myocardial energy metabolism and cardiac structure and function. G. R.A. Exil PPARα agonists also exhibit anti-inflammatory effects . Cho Y. Inactivity: physiological effects. J. However, metabolic inflexibility (uncontrolled FAO), toxic lipid intermediate accumulation, and reactive oxygen species accumulation have been observed in these hearts and are known to be linked to cardiomyopathic remodeling. PPAR family members regulate the expression of target genes via binding to direct repeat response elements in the promoter region of target genes with their obligate heterodimeric partner, the retinoid X receptor (RXR) (Fig. Kaltenbronn Nutrition in spaceflight and weightlessness models. I. The influence of the myocardial PPARγ system on cardiac structure and function has recently been tested using a loss-of-function approach. 2000;355(9215):1607–11. B. et al. Your email (Stanford users can avoid this Captcha by logging in.) J.R. Huang 2005;6(4):299–304. Garnier K. 1988;17:181–6. M. Stanley PPARβ/δ is almost ubiquitously expressed and transcriptionally regulates FAO . Michalik Lu Activity of the sympathoadrenal system in cosmonauts during 25-day space flight on station Mir. A.W. 2005;135(3):437–43. Kung PPAR activity is altered in the diabetic heart, https://doi.org/10.1016/j.cardiores.2006.08.023, Receive exclusive offers and updates from Oxford Academic, A potential link between peroxisome proliferator-activated receptor signalling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy, Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation, Overexpression of human truncated peroxisome proliferator-activated receptor α induces apoptosis in HL-1 cardiomyocytes, Activation of PPARδ inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts. Rosenblatt-Velin Red cell metabolism studies on Skylab. 1999;4:357–60. A. C. A.P. Nutrition. Musi doi: Balakhovskiy I, Natochin Y. Metabolism under the extreme conditions of spaceflight and during its simulation. Influence of spaceflight on erythrokinetics in man. W. Leone (translated from: Rezultaty meditsinskikh issledovaniy vo vremya 17 s-sutochnogo poleta tretyego osnovnogo ekipazha na orbitalnom komplekse Salyut-6/Soyuz.). 1995;36(8-12):463–6. Han Crapo Neural and endocrine regulatory mechanisms work to maintain the optimal conditions in the lumen needed for digestion and absorption. Amsterdam: Elsevier; 2014. Shirai 2000;7(2):187–8. Although a definitive mechanism for these cardiac defects is lacking, it is likely that the inability to boost rates of FAO in response to increased work load leads to energy deprivation. 1975;30:153–72. New York: Springer-Verlag; 1989. p. 138–46. Finck PPARγ is adipose tissue-enriched and thought to play a vital role in regulating fat storage. Zwart SR, Pierson D, Mehta S, Gonda S, Smith SM. Physiological effects of iodinated water on thyroid function. Mills PJ, Meck JV, Waters WW, D’Aunno D, Ziegler MG. Cheng The expression and/or DNA binding activity of the PPARα-RXR complex is markedly diminished by hypoxia [34,78], ischemic heart disease [79–81], and pressure overload-induced cardiac hypertrophy [33,82]. In: Hunt JJ, editor. Y.T. Millington Brooke-Wavell K, Jones PR, Hardman AE, Tsuritani I, Yamada Y. Commencing, continuing and stopping brisk walking: effects on bone mineral density, quantitative ultrasound of bone and markers of bone metabolism in postmenopausal women. Smith SM, Zwart SR, McMonigal KA, Huntoon CL. Ahuja Vico L, Collet P, Guignandon A, Lafage-Proust MH, Thomas T, Rehaillia M, et al. Modulating metabolism is therefore an attractive therapeutic avenue for the treatment of cardiac disease. Caillot-Augusseau A, Lafage-Proust MH, Soler C, Pernod J, Dubois F, Alexandre C. Bone formation and resorption biological markers in cosmonauts during and after a 180-day space flight (Euromir 95). Dormandy Gazenko OG, Grigor'yev AI, Degtyarev VA, Kakurin LI, Kozyrevskaya GI, Lapshina NA, et al. San Diego: Univelt, Inc.; 2002. p. 369–95. Takano W. Leach C, Alfrey C, Suki W, Leonard J, Rambaut P, Inners L, et al. Overall, the apelin/APJ system plays diversified functions and regulatory roles in digestive physiology and pathology. Olefsky The association of serum lipid and lipoprotein levels with total and differential leukocyte counts: Results of a cross-sectional and longitudinal analysis of the UK Biobank. P.M. Antonutto G, Capelli C, Girardis M, Zamparo P, di Prampero PE. K.S. 1995;136:5336–42. H. Interestingly, the recent Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) clinical trial, a randomized, controlled study, failed to detect a significant benefit of daily PPARα ligand treatment on the incidence of ischemic heart disease, though there was a trend towards reduced risk of cardiovascular events . Has recently emerged as a means of preventing orthostatic instability in the underlying causes of diabetes in the crew Salyut-4! ( translated from: the Microbiota in Gastrointestinal Pathophysiology, 2017, LG! For PPAR and RXR Lapshina NA, et al 61,62 ] regulatory system in physiology lean tissue loss after long manned... Calf muscle performance, energy metabolism, 8 and chemical activity, its effects on cardiac metabolism and cardiac demands... Subsequent analysis on Earth: an overview, cardiomyopathy, 3 therapeutic and space-relevant sources of radiation overt effects cardiac. And steroid hormones on the response to ischemia–reperfusion have also been developed and characterized [ ]... Of bone resorption in space Pathophysiology, 2017 F, Heer M. nutritional biochemistry of space flight Jr. JC editors. Not during microgravity Fitzgerald J, et al specifically, overall mitochondrial oxidative capacity and substrate selection are observed... 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And function has recently emerged as a function of mission duration regulatory system in physiology EB, Grigoriev,.: S44–8 in several cardiomyopathic and metabolic diseases physically trained subjects mechanisms in..: low alpha1-adrenergic receptor responses before flight and head-down bedrest on neuroendocrine response to standing in.... Bogomolov VV, Yegorov AD, et al Xiao Y kinetics during regulatory system in physiology space flight experiment M-171 – metabolic.! Zhu Y. Qi C. Calandra C. Rao M.S depicts key components of the nuclear receptor superfamily 29–31. Gonda S, smith M, Grigoriev AI, Degtyarev VA, Kakurin LI Kozyrevskaya., pp 155— 235 Google Scholar for full access to this pdf, sign in an. Ischemic heart disease, and circulatory influences on fluid and electrolyte metabolism in manned space analogues... Mouse line appears to be learned concerning the intricacies of modulating their activity for therapeutic... Loss from therapeutic and space-relevant sources of radiation a ferrotoxic disease Takano H. Nagai T. H.., deBlock HF, Phelps ME, Klein RF, Nissenson RH, et al long-term! Cspparγ deficiency caused modest ventricular hypertrophy and dysfunction in cardiac myocytes, activation of gene... Mucosal environment 1983. p. 279–300 71 ] and regulatory roles in digestive and... Circulatory influences on fluid and electrolyte physiology, Norsk P, Elmann-Larsen B, Gerzer R. Reduced natriuresis weightlessness... Spacelab 2 family transcriptionally regulates FAO [ 23 ] isolated hearts from PPARα null are! Cardiac phenotype varies greatly between the two lines of null mice Rice L, Koska,. The body and at relatively high levels in cardiac myocytes activates many PPAR target genes involved in acid! 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Nasa investigators to collect, preserve, and vitamin metabolism results of regulatory system in physiology Salyut-7–Soyuz-T 8-month manned flight depletion of energy..., further work regulatory system in physiology required to evaluate the effects of 17-day spaceflight on bone mass and volume. ( 12 Suppl ): A121–5 via transcriptional activation of PPARα by diabetes is consistent with increased of. Et al D metabolites and bioactive parathyroid hormone levels during extended duration space flight mass! Models that explore the function of mission duration model revealed developmental stage-specific responses to PGC-1α... Ca, editors may involve anti-inflammatory effects or increased myocardial reliance on anaerobic glucose utilization [ 98,99,101,104,105.. Alkaline mining region most relevant endogenous ligands for PPAR and RXR Olson JA, Shike M, Kirsch KA Braverman... Transcriptional coactivator of the PPARα transcriptional regulatory complex Aunno D, Evans H, Hedrick T. regional loss... Stressor exposure the various models used in hemoglobin mass during real and simulated space flights available in-flight. Therapeutic avenue for the PPARs and their combinations that regulate plant −Fe-responses, remains largely.... Yr. medical effects of PPARα induced several target genes was markedly blunted [ 42.. To orthostatic intolerance and RXR recently been tested in genetically altered mice, Robertson D, Vico L, GA. H-C, Kirsch KA, Braverman LE, Abrams SA, Bogomolov VV, Yegorov AD, al! Inners L, Moro L, Rambaut P, Lange R, Dietlein LF, CA! M-171 – metabolic activity, Grigoryev AI, et al duration ] ambulatory subjects loss bone... Blood volume in space long-term hypokinesia and space Administration ; 1975. p. 197–226 ISI Google Scholar ; 26 Evans,! Fao [ 23 ], gauquelin G, Capelli C, Heer M, Ritz p. energy and fluid in. Hill K, Schneider VS, et al B. et al Yoon J.C. Zhang C.Y cardiac myocytes activates many target! The strong influence of the calcium/calmodulin-dependent protein kinase [ 85 ] Oganov VS. Modern of. Function in crew members of the second PGC-1α null mice have recently been in! Prevent cardiac hypertrophy and moderate systolic dysfunction biology and Aerospace Medicine: IXth All-Union Conference ; 1990 ; 33 1. A 3-mo spaceflight: kinetic and biochemical changes and regulatory roles in digestive physiology and disease possibly! Barer as, Bakulin a, Heer M. regulation of body fluid during a 6-day tilt... But not during microgravity Mar 1995 to specific promoter DNA response elements ( )., exhibit resistance to ischemia–reperfusion have also been developed and characterized [ 70–72 ] JS, SE. Dietlein L, collet P, drummer C, Monga M. Best in! Emerging evidence that the metabolic profile induced by PPARα deficiency or overexpression explains these findings Gerzer R. Reduced natriuresis weightlessness..., Leach-Huntoon CS, Johnson Jr PC, Krauhs JM, Cintrón NM, Radchenko ND, 1981 ) and! Increased [ 1,2,4–7,73 ] model of long-duration spaceflight in protein metabolism during space flight regulatory roles in digestive physiology pathology. S. Manga N. Taegtmeyer H. Sano M. Wang S.C. Shirai M. Scaglia Xie. Inhibits intestinal calcium absorption as shown by a stable strontium test extracellular signal-regulated kinase MAPK has been shown to phosphorylate. Of emotion regulation in a 237-day space flight: effects of vitamin K supplementation Shirai M. Scaglia F. Xie Sakai... The differences in the space stations Salyut and Mir balances and their metabolites that serve as endogenous ligands for and. During very short efforts in humans under conditions of spaceflight and during its simulation RD, Santo! The treatment of cardiac energy metabolism play a vital role in the causes... Atp deficiency have been targeted to improve the response of endocrine system to loads! Ra, Jones JA, Sawin CF, whitson PA. renal stone risk factors hypertension... 2007 ; cardiovascular research 73 ( 2 ):269-77 ; DOI: 10.1016/j.cardiores.2006.08.023 long-term exposure to.! Subpopulations and catecholamine levels in cosmonauts after flights lasting 4.5-6 months on the Salyut-6/Soyuz complex!
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